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The HRB CRF-C is equipped to support Academic/Clinical Investigators by providing the infrastructure, facilities and experienced research and specialist support staff to successfully conduct world-class patient-focused research in a safe and regulated environment to international standards. The HRB CRF-C staff have a wealth of experience in patient focused clinical research and also in supporting applications to a variety of funding award schemes. They can provide advice on and assistance with:

  • Clinical Operations Staff
  • Clinical Trial Project Management
  • Quality and Regulatory Affairs
  • Audit and Monitoring
  • Pharmacovigilance
  • Data Management
  • Statistics

Please see below a list of Academic Clinical Investigations supported by the HRB CRF-C.


academic studies
CodeStudyPrincipal InvestigatorDepartmentStatus
12-CRFC-04A randomised controlled trial to investigate the long term effects of an enteral nutritional supplement enriched with eicosapentaenoic acid on body composition, physical activity, immune function and quality of life in patients undergoing treatment of localised oesophageal cancer Dr. Aoife Ryan UCC School of Food & Nutritional SciencesClosed
12-CRFC-45Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel. Dr. Aoife Ryan UCC School of Food & Nutritional SciencesClosed
12-CRFC-47A Prospective Investigation of baseline nutritional status, lifestyle, quality of life and performance status in newly diagnosed cancer patients: effects on cancer stage, treatment tolerance and survival Dr. Aoife Ryan UCC School of Food & Nutritional SciencesClosed
16-CRFC-47The impact of body composition parameters on ipilimumab toxicity and survival in patients with metastatic melanoma Dr. Aoife Ryan UCC School of Food & Nutritional SciencesClosed
17-CRFC-15Pilot Human studies of appetite enhancing Lead functional compound Dr. Aoife Ryan UCC School of Food & Nutritional SciencesRecruiting
15-HRB CRF-C-06The Natural History of Cystic Fibrosis Liver Disease- Refining the Phenotype Dr. Barry Plant Respiratory MedicineClosed
15-HRB CRF-C-23INCA SUn: A prospective randomised multicentre study to optimise the management of Symptomatically Uncontrolled asthma. Dr. Des MurphyRespiratory MedicineRecruiting
17-CRFC-33Body composition determinants of radiation dose during abdominopelvic CT. Professor Michael MaherRadiologyClosed
17-CRFC-25Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE) Dr. Ruben KeaneQuality & Regulatory AffairsRecruiting
12-CRFC-01Baseline 2: Early life composition exploring the origins of Childhood obesity and metabolic Dysfunction though the Bnaseline Cohort Dr Deirdre MurrayPediatricsAnalysis
13-HRB CRF-C-08Prospective randomized placebo controlled double blind multicenter (phase 3) trial to evaluate clinical efficacy and safety of avian polyclonal anti-pseudomnas antibodies in prevention of recurrence of pseudomonas aeruginosa infection in cystic fibrosis patients. (IMPACT) Dr. Ni CroninPediatricsClosed
12-CRFC-26An International, Open Label, Randomised Controlled Trial Comparing Rituximab With Azathioprine as Maintenance Therapy in Relapsing ANCA-associated Vasculitis Dr. Michael ClarksonNephrologyClosed
12-CRFC-53ACR/EULAR endorsed study to develop classification and diagnostic criteria for primary systemic vasculitis Dr. Michael ClarksonNephrologyClosed
13-HRB CRF-C-12Nephrology Rare Disease Biorepository Dr. Michael ClarksonNephrologyClosed
13-HRB CRF-C-20Randomized Trial of Superficial Nosocomial Infections in Radica™Compared to Routinely Cleaned Isolation Rooms Prof. Joe EustaceNephrologyClosed
16-HRB CRF-C-02Irish Rare Kidney Disease and Vasculitis Registry and Bioresource Dr. Michael ClarksonNephrologyRecruiting
15-HRB CRF-C-01Effect of short-term vitamin D supplementation on urinary and serum calcium levels in a group of hypercalcemic vitamin D deficient renal transplant recipients. Professor Joe EustaceLeadershipAnalysis
16-CRFC-25Comparison of two diets with different phosphorus contents and bioavailability on serum phosphate levels in haemodialysis Professor Joe EustaceLeadershipAnalysis
16-CRFC-30Decreasing Intakes & Absorption of Phosphorus in Haemodialysis Patients through Food Choices DIP HD Professor Joe EustaceLeadershipAnalysis
16-CRFC-06Prospective study of Myeloma related VTE Dr. Susan O'SheaHematologyClosed
13-HRB CRF-C-18A cross sectional observational study to measure physical activity levels od medicated patients aged 65 and over in the acute hospital setting. Dr. Susan Timmons GeriatricsClosed
14-HRB CRF-C-17Randomized conbtrolled trial to measure the effects of an augmented prescribed exercise program on mobility, quality fo life and healthcare utilisation for frail hospitalized older medical in-patients Dr. Susan Timmons GeriatricsAnalysis
15-HRB CRF-C-27Peripheral AKT levels in Parkinsons Disease Dr. Susan Timmons GeriatricsClosed
15-HRB CRF-C-24The knowledge, attitudes and beliefs of carers (parents, guardians, healthcare practitioners, crèche workers) around fever and febrile illness in children Dr. Frances ShielyEducationClosed
14-HRB CRF-C-10CABG Transfusion Risk Prediction Mr. John HinchonCardiothoracic SurgeryClosed
11-CRFC-07Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction Dr. Dorothy BreenAnaestiologyClosed
15-HRB CRF-C-20Clinical Investigation of RespiraSense measurement of respiratory rate compared to standard care in patients discharged from ITU Dr. Dorothy BreenAnaestiologyClosed
16-CRFC-26Simulated learning program for central catheter placement Dr. Dorothy BreenAnaestiologyClosed
11-CRFC-04A Randomised Trial Evaluating the Safety and Efficacy of a Single Low Dose of Intracoronary Insulin-like Growth Factor-1 following Percutaneous Coronary Intervention for ST-Elevation Acute Myocardial InfarctionAnalysis
11-CRFC-05Multi-modal effects of Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism; a randomized placebo-controlled Trial Professor Patricia KearneyClosed
11-CRFC-08Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn Dr. Eugene DempseyRecruiting
12-CRFC-06Development and clinical trials of a new Software ENgine for the Assessment & optimization of drug and non-drug Therapy in Older peRsons (SENATOR) Professor Denis O' MahonyAnalysis
12-CRFC-07Cork Children's Lifestyle study Professor Ivan PerryClosed
12-CRFC-12Safeguarding the brain of our smallest children – an investigator-initiated randomised, blinded, multinational, phase II feasibility clinical trial on near-infrared spectroscopy monitoring combined with defined treatment guidelines versus standard monitoring and treatment as usual in premature infants Dr. Eugene DempseyClosed
12-CRFC-39A Study to Determine the Extent of Respiratory Limitation Post Renal Transplantation Dr. Des MurphyAnalysis
12-CRFC-41RCT of Omega 3 Fatty acids compared to placebo in the prevention of psychosis in very high risk individuals. Dr. Maeve RooneyRecruiting
12-CRFC-42Biomarkers and Imaging Of Vulnerable Atherosclerosis in Symptomatic Carotid artery disease Dr. Simon CroninClosed
12-CRFC-44Lifestyle transitions and trajectories through the Lifecourse: Enhancing capacity in Irish cohort and cross-sectional studies Professor Patricia KearneyClosed
13-HRB CRF-C-03A multi-centre, randomised, controlled, clinical Investigation of a standalone decision support Algorithm for Neonatal Seizure Recognition Professor Geraldine BoylanAnalysis
13-HRB CRF-C-07Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified Professor Barry PlantRecruiting
13-HRB CRF-C-10Secure Laparoscopic Retractor for Small Bowel Manipulation in Minimally-Invasive Surgery Dr. Padraig Cantillon MurphyClosed
13-HRB CRF-C-11A Smart Real-time 3D Navigation Platform for Endoscopic Lung Biopsy Dr. Marcus KennedyClosed
13-HRB CRF-C-13A European multicentre double-blind placebo-controlled phase III trial of nilvadipine in mild to moderate Alzheimer’s disease Professor Willie MolloyClosed
14-HRB CRF-C-04Identification of early markers of diabetic nephropathy through analysis of urinary signature proteins and comparison with serum samples Dr. Brenda GriffinClosed
14-HRB CRF-C-05A randomised blinded placebo controlled trial of hydrocortisone in critically ill patients with septic shock Dr. Patrick SeigneClosed
14-HRB CRF-C-07A single blind placebo controlled cross over study of pylopass versus placebo in subjects who are Helicobacter pylori carriers and with mild indegestion Dr. Martin BuckleyClosed
14-HRB CRF-C-11Risk adapted approaches to the management of academic clinical trials Professor Patricia KearneyAnalysis
14-HRB CRF-C-16A Randomized Controlled Trial Of Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction. Professor Louise KennyClosed
14-HRB CRF-C-18A Prospective Assessment of the Biological Burden of Stress in Caregivers: Impact on Cognitive Performance, Mood and the Benefits of Mindfulness Dr. Gerard ClarkeClosed
14-CRFC-08A prospective randomised multicentre study to optimise the management of symptomatically uncontrolled asthma patients. Dr. Des MurphyClosed
15-HRB CRF-C-02Hospital Infection Control and Hygiene Quality Improvement Programme 2015 Dr. Colman CaseyRecruiting
15-HRB CRF-C-03Can Implementation of an Emmergency Department monitoring and ascalation protocol for adult patients reduce the number of critical incidents and improve timely interventions in patients requiring a higher level of care and improve outcomes Prof. Ronan O'SullivanClosed
15-HRB CRF-C-05A phase 1b, open label, uncontrolled, non randomised dose-escalation study to examine the safety of intramuscular autologous transplantation of escalating doses of mesenchymal stem cells to patients with no option critical limb ischemia Professor Tim O'BrienRecruiting
15-HRB CRF-C-12The association of asthma severity with chronic pulmonary aspiration, altered pulmonary microbiota and airway remodelling. Dr. Des MurphyAnalysis
15-HRB CRF-C-13A study to assess the prevalence of Exercise-induced bronchoconstriction and Asthma in Intercounty hurlers. Dr. Des MurphyClosed
15-HRB CRF-C-14Clinical Implications and utility of an endotixin tolerant (ET) state in Cfystic Fibrosis Professor Barry PlantClosed
15-HRB CRF-C-15Description of Symptom burden and health-related quality of life of 893 Patients on haemodialysis in England and Ireland. Professor Barry PlantClosed
15-HRB CRF-C-21Standard issue transfusion versus fresher red blood cell use in intensive care: A randomized trial Dr. Patrick SeigneClosed
15-HRB CRF-C-25Evaluating the Impact of the Systematic Implementation of Advance Care Directives and Palliative Care Education on Quality of Care at End of Life in Long Term Care Settings Professor Willie MolloyAnalysis
15-HRB CRF-C-26Development and clinical trials of a new Software ENgine for the Assessment & optimization of drug and non-drug Therapy in Older peRsons (SENATOR) RCT Professor Denis O' MahonyRecruiting
16-HRB CRF-C-03CK-DHF1-CI-001Comparison of Quantitative Healing Measures Following Standard Intramedullary Nailing of Diaphyseal Tibial Fractures Professor James HartyAnalysis
16-CRFC-11Inflammatory mediators of Ideopathic Pumonary fibrosis study Dr. Mike HenryAnalysis
16-CRFC-14T cell activation protocol Dr. Anna MooreClosed
16-CRFC-18Stress in type I Diabetes Mellites Dr. Stephen O'RiordanRecruiting
16-CRFC-19Personalised prospective comparison of ARni with ArB in patients with natriuretic peptide eLEvation Dr. Mark LedwidgeRecruiting
16-CRFC-20Evaluation of the gall bladder microbiome Mr Cristoir Ó SuillabháinRecruiting
16-CRFC-21Enhancing malignant melanoma immunological engagement using sequential therapy with ipilimumab and electrochemotherapy Dr. Derek PowerRecruiting
16-CRFC-27Athletic Groin Pain (Part 3): An individualized biomechanical approach to rehabilitation Dr Eanna FalvyClosed
16-CRFC-29Irish Prostate Cancer Outcome Research Mr Paul SweeneyRecruiting
16-CRFC-31Placental growth factor in assessment of women with pre-eclampsia to reduce maternal morbidity: Randomised Controlled Trial Professor Louise KennyRecruiting
16-CRFC-33VTC risk assessment and prevention of hospital acquired thrombosis in medical patients in an Irish tertiary care centre Dr. Susan O'SheaClosed
16-CRFC-34Ankylosing Spondylitis Registry of Ireland Dr. Grainne MurphyRecruiting
16-CRFC-36Colchine for Prevention of Vascular Inflammation in Non-cario Embolic Stroke Dr. Simon CroninRecruiting
16-CRFC-37OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People Professor Denis O' MahonyRecruiting
16-CRFC-40CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial Dr. Conor DeasyRecruiting
16-CRFC-43Tranexamic acid for the treatment of gastrointestinal haemhorrage n international randomised, double blind placebo controlled trial Dr. Conor DeasyRecruiting
16-CRFC-46Parental knowledge, attitudes and beliefs on fever: a cross-sectional study in Ireland. Dr. Laura SahmClosed
17-CRFC-16Procalcitonin Dr. Deirdre O'BrienRecruiting
17-CRFC-32CORK study in CF: Low dose chest CT support enhanced mucociliary clearance post ivacaftor. Professor Barry PlantClosed
17-CRFC-35Building a risk calculator to inform prostate cancer diagnosis Mr. Frank O'BrienSet-up
17-CRFC-36Assessments of benefits of FastFoam Dr. Colman CaseyClosed
17-CRFC-37Development of electroporation for Pancreatic/Liver cancer Mr Cristoir Ó SuillabháinSet-up